The defective responsiveness of body tissues to insulin is believed to involve the insulin receptor. Correlation between cardiovascular disease and diabetes mellitus. This translates to a projected rise of diabetes from 171 million in 2000 to well over. Several pathogenic processes are involved in the development of. Efficiency of co expression of transcription factors pdx1, ngn3, neurod and pax6 with insulin. Methods we searched pubmed to capture all metaanalyses and mendelian randomization studies for risk factors of t2dm. The present study is the first to investigate associations between physical activity levels and sociodemographic and health. The noninsulindependent character of the disease only refers to the treatment required during the natural history of the disease, which caused confusion in the past.
Circular noncoding rna hipk3 mediates retinal vascular. Multiple metabolic aberrations in dm, such as advanced glycation end. Diabetes mellitus related bone metabolism and periodontal disease. Antioxidant phytochemicals against type 2 diabetes british. Lipid peroxidation in diabetes mellitus antioxidants. Pancreas pathology of latent autoimmune diabetes in adults. The chronic hyperglycemia of diabetes is associated with longterm damage. Diabetes is a major cause of morbidity and mortality, though these outcomes are not due to the immediate effects of the disorder. Gene expression analysis for type2 diabetes mellitus a. The domestic cat develops diabetes mellitus that is clinically and pathologically similar to human type 2 diabetes table 1. This high blood sugar produces the symptoms of frequent urination, increased thirst, and increased hunger. Among asthma patients, male gender, african americans race, and history of diabetes mellitus, was associated with higher expression of ace2 and tmprss2.
Diabetes mellitus and periodontal diseases mealey 2006. Pdf diabetes mellitus has now assumed epidemic proportions in many countries of the world. The journal also publishes ada statements, consensus reports, clinically. Type 2 diabetes used to be called adultonset diabetes and noninsulindependent diabetes mellitus niddm. Citescore values are based on citation counts in a given year e. Journal of diabetes research publishes articles related to type 1 and type 2 diabetes.
Journal of diabetes and its complications jdc is a journal for health care practitioners and researchers, that publishes original research about the pathogenesis, diagnosis and management of diabetes mellitus and its complications. In 1997, experts from the american diabetes association introduced a new classification system also used today, which abandoned the terms iddm and niddm and retained the terms type 1 and type 2 diabetes ada 1997. International journal of diabetes mellitus vol 3, issue. Elevated blood glucose is a hallmark of all types of diabetes mellitus, which include type 1 diabetes mellitus, type 2 diabetes mellitus, diabetes mellitus characterized by aspects of both type 1 and type 2 diabetes mellitus, gestational diabetes mellitus gdm, and rare cases of diabetes mellitus caused by, for example. This fundamental abnormality leads to increased circulating insulin levels and concomitant hyperglycemia that, in turn, are thought to be responsible for. The canadian journal of diabetes is accepting submissions for a special diabetes in children themed issue planned for july 2021. While our primary aim is to assist the practitioner in hisher care of such patients, and to afford access to. The american heart association ideal cardiovascular health and incident type 2 diabetes mellitus among blacks. Recent journal of diabetes and its complications articles. Maturity onset diabetes of youth mody is a rare type of diabetes that may be inherited as an autosomal dominant condition. Challenge of type 1 diabetes mellitus ilar journal oxford.
Type ii diabetes mellitus is a complex disease with protean clinical manifestations characterized, at its core, by tissue resistance to insulin. Table of contents journal of diabetes research hindawi. Jun 25, 2015 diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Screening and diagnosis is still based on world health organization who and american diabetes association ada criteria which include both clinical and laboratory parameters. Identifying candidate genes for type 2 diabetes mellitus. Diagnosis and classification of diabetes mellitus ncbi. Diabetes mellitus service temporarily down world health. Gestational diabetes mellitus gdm is a severe threat to the health of both mother and child. Aims and scope the primary purpose of journal of diabetes and its complications is to act as a source of information, usable by those caring for patients with diabetes mellitus who are thereby at risk for development of those complications which all too often appear with time. Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Prediabetes is a practical and convenient term referring to impaired.
Prediabetes is a practical and convenient term referring to impaired fasting. Articles on diabetes mellitus diabetes mellitus also known as simply diabetes is a group of metabolic diseases in which there are high blood sugar levels over a prolonged period. Diabetes mellitus list of high impact articles ppts. Diagnosis, classification and pathogenesis of diabetes mellitus. There are a number of different causes of diabetes but by far the majority of cases are classified as either type 1 or type 2 diabetes. Prediabetes is the term used for indi viduals whose. Detailed information for authors hoping to submit their manuscript to diabetes. Many nongenetic risk factors have been suggested, but their overall epidemiological credibility has not been assessed. Diabetes journal diabetes mellitus journal open access. Paul robertson diabetes has provided scientific information in tences in the recently published history of the american diabetes related areas of basic and clinical research diabetes association, the. Who expresses special appreciation to us centers for disease control and prevention for financial. Diabetes mellitus is a chronic endocrine disorder, characterized by hyperglycaemia resulting from absolute or relative insulin deficiency.
Individuals exhibiting precursor symptoms of diabetes mellitus or reaching diagnostic thresholds. Type 1 diabetes is the main focus of this journal issue. Impact of diabetes mellitus arteriosclerosis, thrombosis. The who and the american diabetics association 4,7. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Diabetes mellitus triggers oxidative stress in the liver of alloxantreated rats. Rac1 modulates endothelial function and platelet aggregation. The classical classification of diabetes as proposed by the american diabetes. American diabetes association 2451 crystal drive, suite 900, arlington, va 22202 1800 diabetes follow us on twitter, facebook, youtube and linkedin dbp footer main.
All types of diabetes mellitus have something in common. Papers cover the medical, pathological, biochemical, physiological, and genetic aspects of the subject areas. The worldwide prevalence of diabetes in 2000 was approximately 2. Patients showed statistically significant decreases in their hgba1c, and many were able to reduce their diabetes medication. Pdf classification, pathophysiology, diagnosis and management. Changed bone metabolism is one of the important longterm complications associated. Type 1 diabetes mellitus the american diabetes association provides clear definitions of the various types of diabetes and classification, diagnosis, and clinical care of diabetes. Objective to identify novel modifiable risk factors of gestational diabetes mellitus gdm by examining the association between prepregnancy habitual folate intake and gdm risk. Because it is the most common household pet, the domestic cat shares the same environment with humans and many of the risk factors for diabetes such as physical inactivity and obesity. Gene expression of ace2 was lower than tmprss2, and expression levels of both genes was similar in asthma and health. Uncontrolled diabetes can lead to blindness, limb amputation, kidney failure, and vascular and heart disease. Although mounting evidence suggests that therapy for gdm could improve neonatal health, whether the therapy confers longterm metabolic benefits to offspring in their later adult lives is not known.
Expression of h2s in gestational diabetes mellitus and. Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia. International journal of diabetes and endocrinology. J in silico in vitro abstract diabetes mellitus is a disorder occurs due to metabolic problems is most frequent globally. Insulin therapy for gestational diabetes mellitus does not. This delay in diagnosis could increase the incidence of longterm complications in type 2 diabetes patients since. Srinivas, 5chinta someswararao 1department of cse, s r k r engineering college, bhimavaram 534204, w.
Type 1 dm, which results from destruction of beta cells in the pancreas, accounts for approximately 10 percent of all patients with dm in. Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Perspectives in diabetes history of diabetes, the journal 1 9521 991 editors swan song r. Several pathogenic processes are involved in the development. Microvascular basement membranes in diabetes mellitus. The 1997 american diabetes association ada recommendations. Factors favouring a diagnosis of noninsulindependent diabetes mellitus. The main indication of diabetes mellitus is a hyperglycemia in blood which is due. International journal of diabetes and endocrinology ijde is an online open access journal featuring current research in diabetes and endocrinology, which covers steroid hormones, clinical chemistry and biochemistry, neuroendocrinology, hypoglycemia in diabetes, etc. As such, there are four types or classes of diabetes mellitus viz. Srinivas, and chinta someswararao, iacsit member iacsit international journal of engineering and technology, vol. Topics include etiology, pathogenesis, management, and prevention of diabetes, as well as associated complications such as nephropathy.
Use of mouse models in studying type 2 diabetes mellitus. Type 1 and type 2 diabetes, diabetic nephropathy and retinopathy, gestational diabetes and covers all aspects of diabetes. Pathophysiological characteristics of peripheral arterial disease pad in diabetes mellitus dm. This form of dm is what was previously called noninsulindependent or adult older then 40 years of age diabetes mellitus. Gene expression analysis for type2 diabetes mellitus a case study on healthy vs diabetes with parental history chandra sekhar vasamsetty, iacsit member, srinivasa rao peri, allam appa rao, k. Diabetes mellitus has been known for centuries as a disease related to sweetness. This was mirrored by loss of frontal and parietal cortical structure. T2dm and obesity are affected by comprehensive sets of genes in multiple tissues. Diabetes mellitus, disorder of carbohydrate metabolism characterized by impaired ability of the body to produce or respond to insulin and thereby maintain proper levels of sugar in the blood. The new classification system american diabetes association 2004 identifies four types of diabetes mellitus. Diabetes mellitus is one of the most common diagnoses made by family physicians. Feline models of type 2 diabetes mellitus ilar journal. International journal of diabetes mellitus vol 3, issue 1. Targeted therapies and ai with advancements in ai technology and developing treatment options, the horizon of retinal care is.
Gestational diabetes mellitus gdm is associated with an increased risk of metabolic disorders in offspring in later life. The journal is aimed to provide a forum to discuss etiology and pathogenesis, clinical features, modern diagnostic and. American journal of respiratory and critical care medicine. Both changes were related to worse glycemic control during follow. Background type 2 diabetes mellitus t2dm is a global epidemic associated with increased health expenditure, and low quality of life. Journal of diabetes mellitus rg journal impact rankings. Type 1 diabetes mellitus t1dm is a chronic, lifelong disorder of glucose homeostasis characterized by autoimmune destruction of the insulinproducing pancreatic bcell, leading progressively to. The simple word care may suffice to express the journals philosophical mission. Type 2 diabetes mellitus is that the most typical variety of diabetes 36. Definition, diagnosis and classification of diabetes mellitus and its complications.
Increased expression of vegf in retinal vessels appears to be mediated by pi. Jdm is an international journal dedicated to the current developments of diabetes mellitus, the broad scope will also include significant research in the fields of pathology. Apr 10, 2015 diabetes mellitus and periodontal disease are chronic diseases affecting a large number of populations worldwide. Definition, classification and diagnosis of diabetes, prediabetes. Type 2 diabetes mellitus t2dm and obesity have become increasingly prevalent in recent years. Novel pathways for vascular cell perturbations in diabetes mellitus. Macrovascular and microvascular complications contribute to morbidity and mortality in diabetes mellitus. Jdc also publishes articles on physiological and molecular aspects of glucose homeostasis. Metabolic abnormalities in carbohydrates, lipids, and proteins result from the importance of insulin as an anabolic hormone. Definition, diagnosis and classification of diabetes mellitus. The chronic hyperglycemia of diabetes is associated with longterm damage, dysfunction, and failure of various organs, especially the eyes, kidneys, nerves, heart, and blood vessels. Covid19 pandemic, coronaviruses, and diabetes mellitus. Genetic reconstitution of diabetes as a polygenic disease.
While the american diabetes association defines prediabe. Low levels of insulin to achieve adequate response andor. Recent studies have focused on identifying causal variations or candidate genes for obesity and t2dm via analysis of expression quantitative trait loci eqtl within a single tissue. In this regard, the study heart rate variability as early biomarker for the evaluation of diabetes mellitus progress by r. Diabetes mellitusinduced retinal vascular complication is the major cause of blindness, which is characterized by inflammation, loss of capillaries, increased vascular permeability, and neovascularization. Although classification of diabetes is important and has implications for the treatment strategies, this is not an easy task and many patients do not easily fit into a single class especially younger adults1,46 and 10% of those initially classified may require revision. The pathogenesis of gdm remains unclear, although much research has found that the levels of hydrogen sulfide h 2 s play an important role in complications of pregnancy. Review article diabetes mellitus a devastating metabolic. Classification, pathophysiology, diagnosis and management of. Articles that are accepted for this special edition will be registered in pubmed and fully citable approximately one month after the final draft is accepted for publication. The expression of the oas1 gene was found to be significantly enhanced in t.
Classification of diabetes mellitus is based on its aetiology and clinical presentation. Pkc activation was also observed in cultured endothelial cells under high glucose conditions and in retinal endothelial cells isolated from animal models of diabetes mellitus. Research design and methods the study included 14,553 women in the nurses health study ii who reported at least one singleton pregnancy between the 1991 and 2001 questionnaires. Diabetes mellitus dm is a metabolic disorder characterized by the presence of. Sign up to receive email notifications of new diabetes journal content as soon as it becomes available. Diabetes mellitus type 2 journal articles the retina revolution. Activation of the glp1 receptor by liraglutide increases ace2 expression, reversing right ventricle hypertrophy, and improving the production of spa and spb in the lungs of type 1 diabetes rats. Perspectives in diabetes history of diabetes, the journal. The chronic hyperglycemia of diabetes is associated with longterm damage, dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels.
1101 1008 1310 692 1406 745 1037 1134 875 1107 1313 424 1152 1178 1456 838 782 1142 1030 1498 959 906 624 664 480 260 370 350 801 1059 1393 433 518 1294 601 217 1374 1211 172 1382 205 191 320 527 598